Shortly after beginning a L-asparaginase infusion, a patient reports discomfort. What should the nurse do FIRST?

In the context of administering L-asparaginase, which is known to potentially elicit adverse reactions, the priority action when a patient reports discomfort is to stop the infusion immediately. This is vital because the discomfort could be an indication of an allergic reaction or another serious adverse event. By halting the infusion, the nurse prevents further exposure to the drug, thereby mitigating the risk of escalating symptoms or complications.

Following the discontinuation of the infusion, the nurse can then proceed with additional steps such as notifying the physician, observing for further symptoms, or administering appropriate treatment like antihistamines if indicated. However, the initial and most immediate response must involve stopping the infusion to ensure the patient's safety.